Camel Milk Triggers Apoptotic Signaling Pathways in Human Hepatoma HepG2 and Breast Cancer MCF7 Cell Lines through Transcriptional Mechanism
作者： Hesham M. Korashy , Zaid H. Maayah , Adel R. Abd-Allah , Ayman O. S. El-Kadi , Abdulqader A. Alhaider
DOI: 10.1155/2012/593195
关键词:
摘要: Few published studies have reported the use of crude camel milk in treatment stomach infections, tuberculosis and cancer. Yet, little research was conducted on effect apoptosis oxidative stress associated with human The present study investigated underlying mechanisms proliferation cancer cells using an vitro model hepatoma (HepG2) breast (MCF7) cells. Our results showed that milk, but not bovine significantly inhibited HepG2 MCF7 through activation caspase-3 mRNA activity levels, induction death receptors both cell lines. In addition, Camel enhanced expression markers, heme oxygenase-1 reactive oxygen species production Mechanistically, increase levels by completely blocked transcriptional inhibitor, actinomycin D; implying increased de novo RNA synthesis. Furthermore, Inhibition mitogen activated protein kinases differentially modulated milk-induced levels. Taken together, survival extrinsic intrinsic apoptotic pathways.
hindawi.com参考文章(35)
Z Farah, R Rettenmaier, D Atkins, Vitamin content of camel milk. International Journal for Vitamin and Nutrition Research. ,vol. 62, pp. 30- 33 ,(1992)
Hesham M. Korashy, Mohamed A. M. El Gendy, Abdulqader A. Alhaider, Ayman O. El-Kadi, Camel Milk Modulates the Expression of Aryl Hydrocarbon Receptor-Regulated Genes, Cyp1a1, Nqo1, and Gsta1, in Murine hepatoma Hepa 1c1c7 Cells BioMed Research International. ,vol. 2012, pp. 782642- 782642 ,(2012) , 10.1155/2012/782642
Niki Kontou, Theodora Psaltopoulou, Demosthenes Panagiotakos, Meletios A. Dimopoulos, Athena Linos, The mediterranean diet in cancer prevention: a review. Journal of Medicinal Food. ,vol. 14, pp. 1065- 1078 ,(2011) , 10.1089/JMF.2010.0244
Azad Bonni, Anne Brunet, Anne E West, Sandeep Robert Datta, Mari A Takasu, Michael E Greenberg, Cell Survival Promoted by the Ras-MAPK Signaling Pathway by Transcription-Dependent and -Independent Mechanisms Science. ,vol. 286, pp. 1358- 1362 ,(1999) , 10.1126/SCIENCE.286.5443.1358
EL‐Rashdy M. Redwan, Ashraf Tabll, Camel lactoferrin markedly inhibits hepatitis C virus genotype 4 infection of human peripheral blood leukocytes. Journal of Immunoassay & Immunochemistry. ,vol. 28, pp. 267- 277 ,(2007) , 10.1080/15321810701454839
Hesham M. Korashy, Ayman O.S. El-Kadi, The role of aryl hydrocarbon receptor and the reactive oxygen species in the modulation of glutathione transferase by heavy metals in murine hepatoma cell lines. Chemico-Biological Interactions. ,vol. 162, pp. 237- 248 ,(2006) , 10.1016/J.CBI.2006.07.002
Anca Roseanu, Paula E. Florian, Magdalena Moisei, Livia E. Sima, Robert W. Evans, Mihaela Trif, Liposomalization of lactoferrin enhanced its anti-tumoral effects on melanoma cells. Biometals. ,vol. 23, pp. 485- 492 ,(2010) , 10.1007/S10534-010-9312-6
James B Johnston, Albert F Kabore, Jeanna Strutinsky, Xiaojie Hu, James T Paul, Dianne M Kropp, Brenda Kuschak, Asher Begleiter, Spencer B Gibson, Role of the TRAIL/APO2-L death receptors in chlorambucil- and fludarabine-induced apoptosis in chronic lymphocytic leukemia. Oncogene. ,vol. 22, pp. 8356- 8369 ,(2003) , 10.1038/SJ.ONC.1207004
David M. Hockenbery, Zoltan N. Oltvai, Xiao-Ming Yin, Curt L. Milliman, Stanley J. Korsmeyer, Bcl-2 functions in an antioxidant pathway to prevent apoptosis Cell. ,vol. 75, pp. 241- 251 ,(1993) , 10.1016/0092-8674(93)80066-N
Hesham M Korashy, Anwar Anwar-Mohamed, Anatoly A Soshilov, Michael S Denison, Ayman OS El-Kadi, None, The p38 MAPK Inhibitor SB203580 Induces Cytochrome P450 1A1 Gene Expression in Murine and Human Hepatoma Cell Lines through Ligand-Dependent Aryl Hydrocarbon Receptor Activation Chemical Research in Toxicology. ,vol. 24, pp. 1540- 1548 ,(2011) , 10.1021/TX200141P