A long intergenic non-coding RNA regulates nuclear localization of DNA methyl transferase-1.
作者： Triantafillos Liloglou , John Halsall , Aditi Kanhere , Aditi Kanhere , Susanne Wijesinghe
DOI: 10.1016/J.ISCI.2021.102273
关键词:
摘要: DNA methyl transferase-1 or DNMT1 maintains methylation in the genome and is important for regulating gene expression cells. Aberrant changes activity are commonly observed cancers many other diseases. Recently, a number of long intergenic non-protein-coding RNAs lincRNAs have been shown to play role activity. CCDC26 nuclear lincRNA that frequently mutated hotbed disease-associated single nucleotide changes. However, functional mechanism not understood. Here, we show this concentrated on periphery. Strikingly, absence lincRNA, mis-located cytoplasm, genomic significantly hypomethylated. This accompanied by double-stranded breaks increased cell death. These results point previously unrecognized lincRNA-mediated subcellular localization regulation methylation.
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