Encephalopathy with status epilepticus during sleep or continuous spikes and waves during slow sleep syndrome: a multicenter, long-term follow-up study of 117 patients.

摘要: Summary Purpose To retrospectively analyze the electroclinical features, etiology, treatment and prognosis of 117 patients with encephalopathy status epilepticus during sleep (ESES) or continuous spike waves slow (CSWSS) syndrome a long-term follow-up. Methods Charts ESES/CSWSS followed between 1990 2012 were analyzed. Inclusion criteria were: (1) focal seizures apparently generalized EEG epileptiform discharges; (2) further occurrence atypical absences, myoclonic, atonic, and/or seizures; (3) cognitive impairment behavior disturbances; (4) spike-and-wave discharges in more than 85% non-REM sleep. Patients less also Key findings ‘Mean follow-up from onset was 13 years (range, 2–22 years) symptomatic/structural non-idiopathic group consisting 79 children 10.5 2–21 idiopathic 38 children. The comparison clinical localization paroxysmal abnormalities (focal, multifocal, generalized) at different stages (before, during, after ESES/CSWSS) percentage spike-wave index not statistically significant. Significance is an epileptic similar >85% those Among AED responders, cases returned to normality structural baseline development .