Long-term outcome after cognitive and behavioral regression in nonlesional epilepsy with continuous spike-waves during slow-wave sleep

摘要: Summary Purpose:  To present the long-term follow-up of 10 adolescents and young adults with documented cognitive behavioral regression as children due to nonlesional focal, mainly frontal, epilepsy continuous spike-waves during slow wave sleep (CSWS). Methods:  Past medical electroencephalography (EEG) data were reviewed neuropsychological tests exploring main functions administered. Key Findings:  After a mean duration 15.6 years (range, 8–23 years), none patients had recovered fully, but four regained borderline normal intelligence almost independent. Patients prolonged global intellectual worst outcome, whereas those more specific short-lived deficits best. The marked disorders resolved in all one patient. Executive neither severely nor homogenously affected. Three frontal syndrome active phase (AP) disclosed only mild residual executive social cognition deficits. gains occurred shortly after AP, qualitative improvements continued occur. Long-term outcome correlated best CSWS. Significance:  Our findings emphasize that recovery cessation CSWS depends on severity initial regression. None our major preserved intelligence, reported early destructive lesions lobes. Early recognition rapid introduction effective therapy are crucial for possible outcome.