The spectrum of acquired cognitive disturbances in children with partial epilepsy and continuous spike-waves during sleep: A 4-year follow-up case study with prolonged reversible learning arrest and dysfluency

摘要: We report a longitudinal study (7-l 1 years) of previously normal boy (MR) who presented from the age 5 years with rare partial motor seizures and atypical ‘absences’. The history revealed stagnation in development speech difficulties few months before onset his epilepsy. first waking electroencephalogram (EEC) showed generalized discharges during hyperventilation. Magnetic resonance imaging an arachnoid cyst frontotemporal region. Although epilepsy never became severe, he experienced important learning difficulties. Subsequent EEGs increasingly active left focal epileptic activity continuous spike-waves sleep (CSWS) present EEG. neuropsychological evaluation (7 dysfluency, word finding naming problems, inattention low intelligence quotient. Carbamazepine was changed to clobazam later ethosuximide added rapid improvement (within month) linguistic cognitive performances as well behaviour. Furthermore, patient considerable progress acquisition over next whereas read had been very difficult. gradually disappeared able follow regular school at age-appropriate level. This case adds new facet already recognized more obvious acquired disturbances known occur some childhood syndromes CSWS (aphasia, dementia). It manifested prolonged insidious subtle language disability. documents specific change anti-epileptic drugs restored immediate long-term capacity, suggesting direct but ‘hidden’ role