A unique red-emitting two-photon fluorescent probe with tumor-specificity for imaging in living cells and tissues.
作者： Xiuqi Kong , Baoli Dong , Nan Zhang , Chao Wang , Xuezhen Song
DOI: 10.1016/J.TALANTA.2017.06.023
关键词:
摘要: Tumor-specific imaging can provide an attractive approach for the early detection and prognosis of cancer, as well precise image-guided tumor-removal surgery. Herein, we describe a unique red-emitting two-photon fluorescent probe (N-BN) tumor-specific imaging. N-BN utilized Nile Red fluorophore employed biotin ligand. In presence variety biomolecules or in different pH buffers, fluorescence intensity at 655nm showed no noticeable change. exhibited remarkable absorption cross sections 15.4g under excitation 800nm. Under guidance biotin, be applied biotin-receptor positive cancer cells over biotin-negative one- manners. Assisted by high-definition three-dimensional imaging, living tumor tissues loaded with could display strong red penetration depth about 90µm. Moreover, vivo ex studies intuitively revealed that track highly property near-infrared manner.
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