Indirect potentiometric determination of α-amino acids with a copper-selective electrode and determination of dopa and methyldopa in pharmaceutical preparations

摘要: Abstract α-Amino acids which form soluble copper complexes can be determined by stoichiometric reaction with an excess of copper(II) phosphate suspension and measurement the ions produced a ion-selective electrode. Amino in range 5 X 10−4−1 10−2 M, separately or as total value, accuracy better than 3%. l -Dihydroxyphenylalanine (dopa) methyl derivative were pharmaceutical preparations without interference from excipients; agreement results USP methods was good.