Dexamethasone Reduces Length of Hospitalization and Improves Postoperative Pain and Nausea After Total Joint Arthroplasty: A Prospective, Randomized Controlled Trial

摘要: Controlling postoperative pain and nausea after total joint arthroplasty remains an important challenge. We conducted a prospective, randomized controlled trial with 120 patients to determine if the addition of perioperative dexamethasone multimodal regimen improves antiemetic analgesic control, enhances mobility, shortens hospital length stay hip knee arthroplasty. Patients administered 10mg intravenous intraoperatively consumed less daily rescue anti-emetic medication, reported superior VAS scores, ambulated further distances, had significantly shorter compared control group (P<0.05). A second, 24-hour dose provided significant additional reduced No adverse events were detected administration intraoperative and/or dexamethasone.