Emerging function of mTORC2 as a core regulator in glioblastoma: metabolic reprogramming and drug resistance
作者： Paul S. Mischel , Timothy Cloughesy , Jun-Feng Bi , Webster K. Cavenee , Si-Han Wu
DOI: 10.7497/J.ISSN.2095-3941.2014.04.004
关键词:
摘要: Glioblastoma (GBM) is one of the most lethal human cancers. Genomic analyses define molecular architecture GBM and highlight a central function for mechanistic target rapamycin (mTOR) signaling. mTOR kinase exists in two multi-protein complexes, namely, mTORC1 mTORC2. These complexes differ terms function, regulation sensitivity. well established as cancer drug target, whereas functions mTORC2 cancer, including GBM, remains poorly understood. This study reviews recent findings that demonstrate regulating tumor growth, metabolic reprogramming, targeted therapy resistance which makes critical target.
sci-hub.se 参考文章(84)
Fredrick J. Rosario, Yoshikatsu Kanai, Theresa L. Powell, Thomas Jansson, Mammalian target of rapamycin signalling modulates amino acid uptake by regulating transporter cell surface abundance in primary human trophoblast cells The Journal of Physiology. ,vol. 591, pp. 609- 625 ,(2013) , 10.1113/JPHYSIOL.2012.238014
D. R. Alessi, M. Andjelkovic, B. Caudwell, P. Cron, N. Morrice, P. Cohen, B. A. Hemmings, Mechanism of activation of protein kinase B by insulin and IGF-1. The EMBO Journal. ,vol. 15, pp. 6541- 6551 ,(1996) , 10.1002/J.1460-2075.1996.TB01045.X
Igor Vivanco, H. Ian Robins, Daniel Rohle, Carl Campos, Christian Grommes, Phioanh Leia Nghiemphu, Sara Kubek, Barbara Oldrini, Milan G. Chheda, Nicolas Yannuzzi, Hui Tao, Shaojun Zhu, Akio Iwanami, Daisuke Kuga, Julie Dang, Alicia Pedraza, Cameron W. Brennan, Adriana Heguy, Linda M. Liau, Frank Lieberman, W. K. Alfred Yung, Mark R. Gilbert, David A. Reardon, Jan Drappatz, Patrick Y. Wen, Kathleen R. Lamborn, Susan M. Chang, Michael D. Prados, Howard A. Fine, Steve Horvath, Nian Wu, Andrew B. Lassman, Lisa M. DeAngelis, William H. Yong, John G. Kuhn, Paul S. Mischel, Minesh P. Mehta, Timothy F. Cloughesy, Ingo K. Mellinghoff, Differential Sensitivity of Glioma- versus Lung Cancer–Specific EGFR Mutations to EGFR Kinase Inhibitors Cancer Discovery. ,vol. 2, pp. 458- 471 ,(2012) , 10.1158/2159-8290.CD-11-0284
Dong Bai, Lynn Ueno, Peter K. Vogt, Akt-mediated regulation of NFκB and the essentialness of NFκB for the oncogenicity of PI3K and Akt International Journal of Cancer. ,vol. 125, pp. 2863- 2870 ,(2009) , 10.1002/IJC.24748
Kenta Masui, Webster K. Cavenee, Paul S. Mischel, mTORC2 in the center of cancer metabolic reprogramming Trends in Endocrinology & Metabolism. ,vol. 25, pp. 364- 373 ,(2014) , 10.1016/J.TEM.2014.04.002
Hailan Liu, Yang Liu, Jian-Ting Zhang, A new mechanism of drug resistance in breast cancer cells: fatty acid synthase overexpression-mediated palmitate overproduction Molecular Cancer Therapeutics. ,vol. 7, pp. 263- 270 ,(2008) , 10.1158/1535-7163.MCT-07-0445
Kevin T Jones, Elisabeth R Greer, David Pearce, Kaveh Ashrafi, Rictor/TORC2 regulates Caenorhabditis elegans fat storage, body size, and development through sgk-1. PLOS Biology. ,vol. 7, ,(2009) , 10.1371/JOURNAL.PBIO.1000060
Erin Currie, Almut Schulze, Rudolf Zechner, Tobias C Walther, Robert V Farese, None, Cellular fatty acid metabolism and cancer Cell Metabolism. ,vol. 18, pp. 153- 161 ,(2013) , 10.1016/J.CMET.2013.05.017
Y. Yao, M. Suraokar, B. G. Darnay, B. G. Hollier, T. E. Shaiken, T. Asano, C.-H. Chen, B. H.- J. Chang, Y. Lu, G. B. Mills, D. Sarbassov, S. A. Mani, J. L. Abbruzzese, S. A. G. Reddy, BSTA Promotes mTORC2-Mediated Phosphorylation of Akt1 to Suppress Expression of FoxC2 and Stimulate Adipocyte Differentiation Science Signaling. ,vol. 6, ,(2013) , 10.1126/SCISIGNAL.2003295
I. Ben-Sahra, J. J. Howell, J. M. Asara, B. D. Manning, Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1 Science. ,vol. 339, pp. 1323- 1328 ,(2013) , 10.1126/SCIENCE.1228792