mTORC2 and Metabolic Reprogramming in GBM: at the Interface of Genetics and Environment
作者： Kenta Masui , Webster K. Cavenee , Paul S. Mischel
DOI: 10.1111/BPA.12307
关键词:
摘要: Metabolic reprogramming is a central hallmark of cancer, enabling tumor cells to obtain the macromolecular precursors and energy needed for rapid growth. Understanding how oncogenes coordinate altered signaling with metabolic cancer harness cellular metabolism its metabolites their survival may yield new insights into pathogenesis. Here, we review recently identified regulatory role mTORC2, downstream effector many cancer-causing mutations, in drug resistance glioblastoma. We further consider emerging concept that mTORC2 connect genetics environmental alterations brain cancer.
sci-hub.se 参考文章(38)
Paul S. Mischel, Timothy Cloughesy, Jun-Feng Bi, Webster K. Cavenee, Si-Han Wu, Emerging function of mTORC2 as a core regulator in glioblastoma: metabolic reprogramming and drug resistance Cancer biology and medicine. ,vol. 11, pp. 255- 263 ,(2014) , 10.7497/J.ISSN.2095-3941.2014.04.004
Kenta Masui, Kazuhiro Tanaka, Shiro Ikegami, Genaro R. Villa, Huijun Yang, William H. Yong, Timothy F. Cloughesy, Kanato Yamagata, Nobutaka Arai, Webster K. Cavenee, Paul S. Mischel, Glucose-dependent acetylation of Rictor promotes targeted cancer therapy resistance Proceedings of the National Academy of Sciences of the United States of America. ,vol. 112, pp. 9406- 9411 ,(2015) , 10.1073/PNAS.1511759112
K. Masui, T. F. Cloughesy, P. S. Mischel, Review: molecular pathology in adult high-grade gliomas: from molecular diagnostics to target therapies. Neuropathology and Applied Neurobiology. ,vol. 38, pp. 271- 291 ,(2012) , 10.1111/J.1365-2990.2011.01238.X
Dong Bai, Lynn Ueno, Peter K. Vogt, Akt-mediated regulation of NFκB and the essentialness of NFκB for the oncogenicity of PI3K and Akt International Journal of Cancer. ,vol. 125, pp. 2863- 2870 ,(2009) , 10.1002/IJC.24748
Kenta Masui, Webster K. Cavenee, Paul S. Mischel, mTORC2 in the center of cancer metabolic reprogramming Trends in Endocrinology & Metabolism. ,vol. 25, pp. 364- 373 ,(2014) , 10.1016/J.TEM.2014.04.002
Erin Currie, Almut Schulze, Rudolf Zechner, Tobias C Walther, Robert V Farese, None, Cellular fatty acid metabolism and cancer Cell Metabolism. ,vol. 18, pp. 153- 161 ,(2013) , 10.1016/J.CMET.2013.05.017
Tomoyuki Mashimo, Kumar Pichumani, Vamsidhara Vemireddy, Kimmo J Hatanpaa, Dinesh Kumar Singh, Shyam Sirasanagandla, Suraj Nannepaga, Sara G Piccirillo, Zoltan Kovacs, Chan Foong, Zhiguang Huang, Samuel Barnett, Bruce E Mickey, Ralph J DeBerardinis, Benjamin P Tu, Elizabeth A Maher, Robert M Bachoo, None, Acetate Is a Bioenergetic Substrate for Human Glioblastoma and Brain Metastases Cell. ,vol. 159, pp. 1603- 1614 ,(2014) , 10.1016/J.CELL.2014.11.025
Renee D. Read, Webster K. Cavenee, Frank B. Furnari, John B. Thomas, A Drosophila Model for EGFR-Ras and PI3K-Dependent Human Glioma PLoS Genetics. ,vol. 5, pp. e1000374- ,(2009) , 10.1371/JOURNAL.PGEN.1000374
C. Choudhary, C. Kumar, F. Gnad, M. L. Nielsen, M. Rehman, T. C. Walther, J. V. Olsen, M. Mann, Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions Science. ,vol. 325, pp. 834- 840 ,(2009) , 10.1126/SCIENCE.1175371
Yue Xiong, Kun-Liang Guan, None, Mechanistic insights into the regulation of metabolic enzymes by acetylation Journal of Cell Biology. ,vol. 198, pp. 155- 164 ,(2012) , 10.1083/JCB.201202056