Deciphering the epidemiology of hepatocellular carcinoma through the passage of time: A study of 1,401 patients across 3 decades.

摘要: Hepatocellular carcinoma (HCC) is one of the most common and lethal cancers globally. With advances in therapy for chronic viral hepatitis, changing social circumstances, increasing practice HCC surveillance, epidemiology expected to change over time. We explored temporal trends Singapore, a multiethnic Asian country, last 3 decades. Patients with were prospectively enrolled stratified into two cohorts (C1, 1988-2002; C2, 2003-2016). Patient tumor characteristics, management, survival compared between cohorts, census was performed on October 31, 2015. There 1,401 patients, mean age at diagnosis C1 C2 60.1 63.5 years, respectively. Male patient preponderance decreased significantly, male female ratio falling from 5.2:1 3.9:1 C2. Hepatitis B, although still predominant risk factor HCC, showed significant decline (76.5% 68.2%), while nonviral etiology increased significantly same period (14.4% versus 25.0%, respectively). Significantly more patients than diagnosed through surveillance (39.2% 11.3%, respectively) had better physical performance (Eastern Cooperative Oncology Group 0, 62.1% 20.4%, While Child-Pugh status comparable, early stage disease (Barcelona Clinic Liver Cancer 0-A, 39.5% 7.4%, respectively), which translated higher median (18.6 months 3.8 months, Conclusion: Over past decades, hepatitis B-related has been decreasing due significantly. Surveillance diagnose important improving outcome HCC. (Hepatology Communications 2017;1:564-571).