The 5' flanking region of the pS2 gene contains a complex enhancer region responsive to oestrogens, epidermal growth factor, a tumour promoter (TPA), the c-Ha-ras oncoprotein and the c-jun protein.

摘要: Expression of the pS2 gene which is transcriptionally controlled by oestrogens in breast cancer cell line MCF-7 oestrogen independent stomach mucosa. We show here that level mRNA can also be increased tumour promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). further demonstrate, using transient transfection assays, -428 to -332 5' flanking sequence contains DNA enhancer elements responsive oestrogens, TPA, EGF, c-Ha-ras oncoprotein and c-jun protein.