The inhibitory effect of various fatty acids on aerobic glycolysis in Ehrlich ascites tumour cells.

摘要: Inhibition of glycolysis in Ehrlich ascites tumour cells by saturated fatty acids, added either form potassium salts or incorporated into phosphatidylcholine liposomes, increases with the increasing carbon atom chain length and is independent concentration within range 0.1 to 1.0 mM. In contrast, inhibition cytosolic fraction from depends on acids. The content ATP incubated acids length, which leads a crossing-over concentrations pyruvate 2-phosphoenolpyruvate. Lowering sum both these metabolites palmitate stearate points not only kinase but also other enzymes early steps glycolysis. Fatty intact inhibit all three key glycolytic affect mainly activity phosphofructokinase. smaller than liver muscles.