Health risk assessment to dioxins, furans and PCBs in young children: The first French evaluation.

摘要: Abstract A total diet study (TDS) was conducted between 2010 and 2016 to characterize the health risk related chemical residues in food of French not breastfed children under three years age (infant TDS). Among targeted substances, polychlorinated dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs) biphenyls (PCBs) have been characterized as they accumulate through chain, especially lipid-rich items, because associated with a number adverse effects humans. Food samples (n = 180) were collected be representative dioxins PCB exposure whole non-breastfed from 1 36 months old prepared consumed (including cooking) prior analysis. Dietary then assessed for 705 3 based on their consumptions recorded 3-consecutive-days record. Levels PCDD/Fs PCBs infant lower than those observed common food, leading significant differences according groups. Mean exposures ranged 0.22 0.44 pg TEQWHO05.kg bw−1.d−1 (0.40–0.65 at 90th percentile), depending group hypothesis considered manage left-censored data. non-dioxin-like 0.87 ng kg (1.55 at percentile) 1–4 3.53 ng kg (5.44 at 13–36 children. For NDL-PCBs, tolerable daily intake (TDI) exceeded some groups, particular older ones. Therefore, appropriate management measures must continue reducing exposure; it concerns mainly milk youngest children, ultra-fresh dairy products fish. PCBs, recommendations fish consumption should reminded. Moreover, toxicity studies focusing mixtures dioxin-like compounds encouraged order take into account effect mixtures.