Reduced expression of peroxisome proliferator-activated receptor alpha in BAL and blood T cells of non-löfgren’s sarcoidosis patients
作者： Muntasir Abo Al Hayja , Anders Eklund , Johan Grunewald , Jan Wahlström
DOI: 10.1186/S12950-015-0071-6
关键词:
摘要: Sarcoidosis is a granulomatous disease affecting in particular the lungs. The peroxisome proliferator-activated receptors (PPARs) play important regulatory roles inflammation. aim of this study was to gain more insight about expression all three PPARs (α, β/δ and γ) sarcoidosis. Bronchoalveolar lavage (BAL) cells peripheral blood were obtained from healthy controls (HC) sarcoidosis patients with Lofgren’s syndrome (LS) without (non-LS). mRNA analyzed total BAL FACS (Fluorescence-activated cell sorting) sorted alveolar macrophages (AM) CD4+ T respectively by comparative RT-PCR. protein AM, CD8+ flow cytometry. In cells, we noticed significantly lower PPARα compared HC. non-LS patients, detected as LS patients. had PPARγ could contribute persistent T-cell driven inflammation noted especially non-resolving sarcoidosis, common
biomedcentral.com
springer.com
core.ac.uk
journal-inflammation.com参考文章(49)
M. Ostadkarampour, A. Eklund, D. Moller, P. Glader, C. Olgart Höglund, A. Lindén, J. Grunewald, J. Wahlström, Higher levels of interleukin IL-17 and antigen-specific IL-17 responses in pulmonary sarcoidosis patients with Löfgren's syndrome Clinical and Experimental Immunology. ,vol. 178, pp. 342- 352 ,(2014) , 10.1111/CEI.12403
P. A. Grimaldi, Lipid sensing and lipid sensors Cellular and Molecular Life Sciences. ,vol. 64, pp. 2459- 2464 ,(2007) , 10.1007/S00018-007-7278-5
Diana I. Albu, Danielle Califano, Dorina Avram, Flow cytometry analysis of transcription factors in T lymphocytes Methods of Molecular Biology. ,vol. 647, pp. 377- 390 ,(2010) , 10.1007/978-1-60761-738-9_23
Luisa Klotz, Martina Schmidt, Thomas Giese, Magdalena Sastre, Percy Knolle, Thomas Klockgether, Michael T. Heneka, Proinflammatory Stimulation and Pioglitazone Treatment Regulate Peroxisome Proliferator-Activated Receptor γ Levels in Peripheral Blood Mononuclear Cells from Healthy Controls and Multiple Sclerosis Patients Journal of Immunology. ,vol. 175, pp. 4948- 4955 ,(2005) , 10.4049/JIMMUNOL.175.8.4948
N Shanthi Paramothayan, Toby J Lasserson, E. Haydn Walters, Immunosuppressive and cytotoxic therapy for pulmonary sarcoidosis Cochrane Database of Systematic Reviews. ,vol. 2006, ,(2006) , 10.1002/14651858.CD003536.PUB2
Anagha Malur, Almedia J. Mccoy, Sergio Arce, Barbara P. Barna, Mani S. Kavuru, Achut G. Malur, Mary Jane Thomassen, Deletion of PPARγ in Alveolar Macrophages Is Associated with a Th-1 Pulmonary Inflammatory Response Journal of Immunology. ,vol. 182, pp. 5816- 5822 ,(2009) , 10.4049/JIMMUNOL.0803504
N Shanthi Paramothayan, Toby J Lasserson, Paul Jones, Corticosteroids for pulmonary sarcoidosis Cochrane Database of Systematic Reviews. ,vol. 2005, ,(2005) , 10.1002/14651858.CD001114.PUB2
F. Idali, J. Wahlström, C. Müller-Suur, A. Eklund, J. Grunewald, Analysis of regulatory T cell associated forkhead box P3 expression in the lungs of patients with sarcoidosis. Clinical and Experimental Immunology. ,vol. 152, pp. 127- 137 ,(2008) , 10.1111/J.1365-2249.2008.03609.X
Saravanan Kanakasabai, Wanida Chearwae, Crystal C. Walline, Wade Iams, Suzanne M. Adams, John J. Bright, Peroxisome proliferator‐activated receptor δ agonists inhibit T helper type 1 (Th1) and Th17 responses in experimental allergic encephalomyelitis Immunology. ,vol. 130, pp. 572- 588 ,(2010) , 10.1111/J.1365-2567.2010.03261.X
Johan Grunewald, Review: Role of Genetics in Susceptibility and Outcome of Sarcoidosis Seminars in Respiratory and Critical Care Medicine. ,vol. 31, pp. 380- 389 ,(2010) , 10.1055/S-0030-1262206