Adipose derived delivery vehicle for encapsulated adipogenic factors.

摘要: Abstract Hydrogels derived from adipose tissue extracellular matrix (AdECM) have shown potential in the ability to generate new vivo. To further enhance adipogenesis, a composite delivery system (CADDS) containing single- and double-walled dexamethasone encapsulated microspheres (SW DW Dex MS) has been developed. Previously, our laboratory published use of MS as an additive adipogenesis angiogenesis grafts. In current work, AdECM CADDS are extensively characterized, addition conducting vitro cell culture analysis. Study results indicate used for minimal cellular lipid content allowing gelation its collagen structure under physiological conditions. Adipose-derived stem (ASC) studies confirmed biocompatibility with CADDS, was increased experimental groups hydrogel scaffold. demonstrated controlled release SW formulations. The via injectable scaffold combines two biologically responsive components develop minimally, invasive, off-the-shelf biomaterial engineering. Statement significance Scientists doctors yet product patients soft defects. Recently, (adECM) vivo great promise but individually, adECM still limitations terms volume consistency. work introduces novel construct comprised adECM-based (Dex MS). serves not only protein-rich also non-invasive application defect site. methods presented progressive step forward field