Biodegradable silk catheters for the delivery of therapeutics across anatomical repair sites.

摘要: Biodegradable silk catheters for the delivery of therapeutics are designed with a focus on creating porous gradients that can direct release molecules away from implantation site. Though suitable range applications, these drug to transplanted adipose tissue in patients having undergone fat grafting procedure. A common complication grafts is rapid reabsorption large volume transplants. In order prolong retention, biodegradable be embedded into deliver nutrients, growth factors or improve adipocyte viability, proliferation, and ultimately extend retention. Two fabrication methods developed: gel-spinning technique, which uses novel flash-freezing step induce high porosity throughout bulk tube, dip-coating process using protein solutions doped water soluble porogen. Increased aids diffusion through tube controllable way. Additionally, we interface tubes ALZET osmotic pumps subcutaneous nude mouse model. The work described herein will discuss processing parameters as well interfacing between pump cargo therapeutic resulting profiles. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2018. Biomater 107B: 501-510, 2019.