Effects of various anticoagulant treatments on von Willebrand factor release in unstable angina

摘要: Abstract OBJECTIVES We tested the hypothesis that different anticoagulant treatments may produce platelet effects and von Willebrand factor (vWf) release in unstable angina. BACKGROUND The early increase of vWf has been reported to be a risk for adverse outcome Anticoagulant drugs play key role stabilization angina, but they not have same efficacy on acute release. METHODS studied 154 patients enrolled several clinical trials testing four angina or non-Q-wave myocardial infarction. Patients were treated during at least 48 h by either intravenous unfractionated heparin, one two low molecular weight heparins (enoxaparin dalteparin) direct thrombin inhibitor PEG-hirudin. All received aspirin no IIb/IIIa inhibitors. RESULTS over first (Δ vWf) did relate baseline characteristics. At 30 days follow-up, Δ was sevenfold higher with an end point (death, infarction, revascularization) than free events (+53 ± 7% vs. +7 14%, p = 0.004). trend present each component composite highest levels one-month mortality (+87 32% +26 8%, 0.09). values receiving enoxaparin PEG-hirudin (+10 9% −5 20%, respectively). A serious rise measured heparin-treated 11%), which differed significantly from group (p 0.0006) CONCLUSIONS confirm that, patients, is associated impaired days. Moreover, here do provide protection regards release, important prognostic implications explain results observed recent trials.