Enhanced Shear-Induced Platelet Aggregation in Acute Myocardial Infarction
作者： Shinya Goto , Hiroyuki Sakai , Mami Goto , Miyuki Ono , Yasuo Ikeda
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摘要: Background—Experiments under controlled flow conditions indicate that the binding of von Willebrand factor (vWF) to platelet glycoprotein (GP) Ibα and integrin αIIbβ3 (GP IIb/IIIa complex) is crucial for aggregation at elevated shear rates. We have tested how plasma patients with acute myocardial infarction affects this process. Methods Results—Citrated was obtained from 18 within 6 hours onset symptoms 26 control subjects chest pain syndrome without evidence ischemia. Aggregation normal platelets high rates significantly greater in presence patient than inhibited by both anti-GP anti-αIIbβ3 monoclonal antibodies. The observed values (mean±SD) were 47.6±17.8% versus 30.1±9.9% 10 800 s−1 (P<0.01) 32.9±14.1% 17.5±9.5% 7200 (P<0.01), respectively, positively correlated vWF antigen levels ristocetin cofactor activities. In ...
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