Pulmonary Interstitial Disease in Ig Deficiency

摘要: Study objectives To determine the frequency and type of interstitial lung disease (ILD) in consecutive subjects with symptomatic Ig deficiency. Patients One hundred forty-eight repeated respiratory infections Measurements classes IgG subclasses (IgGSCs), response to vaccination, pulmonary function tests, chest radiography, CT scan, Ga scan and, when possible, BAL biopsy. Results Twenty-nine 148 (19 men 10 women aged 18 72 years) had evidence ILD. In 20 subjects, no cause ILD was apparent. The remaining nine cases were ostensibly due identifiable causes. Twenty IgGSC deficiency, 8 common variable immunodeficiency, 1 subject combined IgM plus No isotype deficiency consistently related a specific After administration IV Ig, eight all improved clinically, physiologically, radiologically, occasionally histologically, regardless immunologic or radiologic features. this selective sample, prevalence recurrent (29 subjects; 19.6%) higher than general population (0.8%; p Conclusions is frequent usually involves