Conservative Nature of Oestradiol Signalling Pathways in the Brain Lobes of Octopus vulgaris Involved in Reproduction, Learning and Motor Coordination

摘要: Oestradiol plays crucial roles in the mammalian brain by modulating reproductive behaviour, neural plasticity and pain perception. The cephalopod Octopus vulgaris is considered, along with its relatives, to be most behaviourally advanced invertebrate, although neurophysiological basis of behaviours, including perception, remain largely unknown. In present study, using a combination molecular imaging techniques, we found that oestradiol up-regulated O. vulgaris gonadotrophin-releasing hormone (Oct-GnRH) oestrogen receptor (Oct-ER) mRNA levels olfactory lobes; turn, Oct-ER was regulated NMDA lobes involved learning motor coordination. Fluorescence resonance energy transfer analysis revealed binds causing conformational modifications nuclear translocation consistent classical genomic mechanism receptor. Moreover, triggered calcium influx cyclic AMP response element binding protein phosphorylation via membrane receptors, providing evidence for rapid nongenomic action O. vulgaris. demonstrate, first time, physiological role reproduction,