Role of Tissue Factor in Cancer

摘要: Tissue factor (TF) is a transmembrane glycoprotein that localizes the coagulation serine protease VII/VIIa (FVII/VIIa) to cell surface. The primary function of TF activate clotting cascade. TF:FVIIa complex also activates cells by cleavage G-protein coupled receptor called protease-activated 2 (PAR2). expressed tumor and contributes variety pathologic processes, such as thrombosis, metastasis, growth, angiogenesis. For instance, release TF-positive procoagulant microparticles into circulation these may trigger venous thromboembolism in patients with cancer. on circulating leads coating fibrin traps them within microvasculature facilitates hematogenous metastasis. In addition, TF:FVIIa-dependent activation PAR2 increases growth via an undefined mechanism. One possibility PAR2-dependent signaling expression proangiogenic proteins. Other studies have reported endothelial vasculature express this enhance These results suggest inhibition should reduce several pathways increase This would represent novel approach anticancer therapy. Initial using inhibitors mouse models produced encouraging results. Nevertheless, additional are needed determine if strategy can be successfully translated treatment cancer patients.