Plant-Produced Recombinant Transmission Blocking Vaccine Candidates to Combat Malaria

摘要: Malaria is one of the world’s most devastating infectious diseases, resulting in over half a million deaths annually. No licensed vaccine currently available, although pre-erythrocytic RTS,S advanced stage clinical trials and significantly reduces cases malaria. However, alone will be insufficient to eradicate malaria and, consequently, variety other vaccines targeting erythrocytic sexual stages parasite’s life cycle are under development. The latter comprise transmission blocking (TBVs) that elicit antibodies against surface proteins so prevent development transmission. Therefore, World Health Organization has proposed TBVs as an effective means reduce serve key element potentially eradicating disease. Several TBV candidates development, including subunit based on gametocyte gamete antigens P48/45 P230 zygote ookinete P25 P28. These have proven challenging produce established recombinant systems, part due large number disulfide bonds. recently, plant-based platforms been recruited for production these antigens. Recombinant plants several advantages therapeutic proteins, cost-effectiveness, scalability, lack harbored mammalian pathogens, possession machinery eukaryotic posttranslational protein modifications. Here, we review ongoing efforts expression systems.