Palladium Catalyzed Carbonylative Coupling for Synthesis of Arylketones and Arylesters Using Chloroform as the Carbon Monoxide Source

摘要: We describe a modular, palladium catalyzed synthesis of aryl(hetero)aryl benzophenones and aryl benzoates from halides using CHCl3 as the carbonyl source in presence KOH. The reaction occurs tandem through an initial carbonylation to generate aroyl halide, which undergoes coupling with arylboronic acids, bornonates, phenols. Direct carbonylative indoles at third position has also been accomplished under slightly modified conditions by situ activation C–H bond. Notably, is convenient safe alternation CO gas, provides milder high functional group tolerance, gives products moderate good yields.