Histogenesis and differentiation potential of central neurocytomas.

摘要: The central neurocytoma, a recently identified rare supratentorial brain tumor in young adults, is characterized by intraventricular location and usually benign clinical course. In order to elucidate the histogenesis differentiation potential of this neoplasm, we have undertaken an immunocytochemical molecular biological study four neurocytomas. It was found immunocytochemistry immunoblotting that all tumors express neuron-specific enolase synaptophysin. Western blots also revealed expression synaptic vesicle protein, synapsin I, neurofilament protein glial fibrillary acidic several neurocytomas which failed exhibit immunoreactivity these marker antigens on paraffin sections. Immunocytochemical reactions with antibodies synaptophysin adjacent sections demonstrated coexpression individual cells. neuronal form pp60src protein-tyrosine kinase, oncogene-product specifically expressed nervous system neurons, not detectable two investigated. N-myc, proto-oncogene frequently amplified childhood neuroblastomas, present as single copy gene neurocytomas, indicating amplification involved pathogenesis neurocytoma. accordance ultrastructural evidence synaptogenesis, conclude neurocytoma neuroectodermal consistent commitment for differentiation. Since retain additional differentiation, propose origin from bipotential progenitor cells periventricular matrix, mammalian persists throughout adult life.