Neuropathy associated with monoclonal gammopathies of undetermined significance

作者: Sylvie Gosselin , Robert A. Kyle , Peter James Dyck

DOI: 10.1002/ANA.410300111

关键词:

摘要: Monoclonal proteins (IgM, IgG, and IgA) in the serum or urine of patients with neuropathy may provide a marker for amyloidosis, myeloma, lymphoma, leukemia, Waldenstrom's macroglobulinemia, monoclonal gammopathy undetermined significance (MGUS). The clinical characteristics, course, electromyographic features among neuropathies associated IgM (IgM-MGUS, 31 patients), IgG (IgG-MGUS, 24 IgA (IgA-MGUS, 10 patients) evaluated between 1980 1986 were compared. Four statistically significant differences set IgM-MGUS apart from IgG-MGUS IgA-MGUS neuropathies: (1) higher frequency sensory loss ataxia, (2) nerve conduction abnormality--10 attributes significantly worse (none better), (3) dispersion compound muscle action potential, (4) MGUS cohort than is characteristic without seen at our institution encountered epidemiological surveys. These not thought to be due selection severity biases. Neither amount nor estimated size peak was neuropathy. type anti-myelin-associated glycoprotein antibodies different those antibodies. A simple relationship presence cannot assumed.

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