Receptor Pattern Formation as a Signal for the Capture of Lipoproteins

摘要: Abstract A critical step in the uptake of dietary cholesterol by liver is binding remnant lipoprotein particles to receptors space Disse. We have found that increases content hepactocyte membranes reduces β-very low density lipoproteins (β-VLDL) and decreases internalization. This increase membrane human hepatoma cells (HepG2) produces a similar effect on primary fibroblasts. However, receptor-negative familial hypercholesterolemic (FH) fibroblasts lack ability respond modification. polyclonal antibody directed against C-terminus region apo-B,E-(LDL) receptor importantly affects internalization process, suggesting protein-protein interactions consolidate pattern formation receptors, process triggers propose interferes with this affecting lateral movement organization receptors.