Interrupted vs. continued maintenance therapy in childhood acute leukemia
作者： Derrick Lonsdale , Edmund A. Gehan , Donald J. Fernbach , Margaret P. Sullivan , Daniel M. Lane
DOI: 10.1002/1097-0142(197508)36:2<341::AID-CNCR2820360208>3.0.CO;2-3
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摘要: A total of 313 patients with childhood acute leukemia received a combination vincristine (2 mg/m2/week) and prednisone (60 mg/m2/day); 86% 276 evaluable achieved complete bone marrow remission in median 35 days. When was achieved, were randomized to one three oral maintenance therapies: 6-mercaptopurine (6MP) (75 mg/m2/day), methotrexate (MTX) (25 mg/m2/twice weekly), or cyclophosphamide (CYC) (100 mg/m2/day). Patients receiving therapy further at 2 6 months after the start either continue discontinue therapy. tthe lengths subsequent for vs. were: 37 19 weeks 6-MP patients; 25 14 MTX 29 13 CYC patients. The remissions 57 17 60 40 23 10 Results indicate significant advantage continuing remission.
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