Regioselective acylation of flavonoids catalyzed by lipase in low toxicity media
作者： Athina Kontogianni , Vasso Skouridou , Vasiliki Sereti , Haralambos Stamatis , Fragiskos N. Kolisis
DOI: 10.1002/1438-9312(200110)103:10<655::AID-EJLT655>3.0.CO;2-X
关键词:
摘要: Flavonoid fatty esters were prepared by acylation of flavonoids (rutin and naringin) acids (C8, C10, C12), catalyzed immobilized lipase from Candida antarctica in various solvent systems. The reaction parameters affecting the conversion enzymatic process, such as nature organic acyl donor used, water activity (a w ) system, well concentration have been investigated. At optimum conditions, was 50-60% tert-butanol at a less than 0.11. In all cases studied, only flavonoid monoester identified, which indicates that this lipase-catalyzed esterification is regioselective. Des de flavonoides sont prepares en acylant des (rutine et naringine) par acides gras C12) : cette est catalysee la dans divers solvants. Les parametres reactionnels affectant du procede enzymatique, comme solvant ou donneur d'acyle, l'activite l'eau d'acyle etudies. Dans conditions optimales, le tert-butanol. tous les cas, seul flavonoide identifie, ce qui montre que
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