Spermatozoal RNA as reservoir, marker and carrier of epigenetic information: implications for cloning.

摘要: Contents The mammalian male gamete is transcriptionally silent as a consequence of the highly condensed architecture its chromatin and there also little or no cytoplasm capable supporting translation; however, we now understand that under certain conditions, spermatozoa can translate their mRNAs de novo spermatozoal RNA potentially affect phenotypic traits in offspring. This epigenetic phenomenon may involve transmission extra-chromosomal episomal elements. Recent evidence indicates play role progressive shutdown transcription during spermiogenesis. The presence sperm nucleus potential carrier eipgenetic information to egg prove insightful with regard abysmal success rates for cloning domestic species by somatic nuclear transfer procedures.