Oncologic angiogenesis imaging in the clinic: how and why?
作者： Karen A Kurdziel , Liza Lindenberg , Peter L Choyke
DOI: 10.2217/IIM.11.31
关键词:
摘要: The ability to control the growth of new blood vessels would be an extraordinary therapeutic tool for many disease processes. Too often, promises discoveries in basic science arena fail translate clinical success. While several anti angiogenic therapeutics are now FDA approved, envisioned benefits have yet seen. clinically non-invasively image angiogenesis potentially used identify patients who may benefit from anti-angiogenic treatments, prognostication/risk stratification and therapy monitoring. This article reviews current future prospects implementing imaging clinic.
openaccessjournals.com参考文章(68)
Steven Sourbron, Technical aspects of MR perfusion European Journal of Radiology. ,vol. 76, pp. 304- 313 ,(2010) , 10.1016/J.EJRAD.2010.02.017
Martin Zweifel, Anwar R. Padhani, Perfusion MRI in the early clinical development of antivascular drugs: decorations or decision making tools? European Journal of Nuclear Medicine and Molecular Imaging. ,vol. 37, pp. 164- 182 ,(2010) , 10.1007/S00259-010-1451-Z
R. K. Singh, M. Gutman, C. D. Bucana, R. Sanchez, N. Llansa, I. J. Fidler, Interferons α and β Down-Regulate the Expression of Basic Fibroblast Growth Factor in Human Carcinomas Proceedings of the National Academy of Sciences of the United States of America. ,vol. 92, pp. 4562- 4566 ,(1995) , 10.1073/PNAS.92.10.4562
Feng Xie, John Lof, Terry Matsunaga, Reena Zutshi, Thomas R. Porter, Diagnostic Ultrasound Combined With Glycoprotein IIb/IIIa–Targeted Microbubbles Improves Microvascular Recovery After Acute Coronary Thrombotic Occlusions Circulation. ,vol. 119, pp. 1378- 1385 ,(2009) , 10.1161/CIRCULATIONAHA.108.825067
L. M. Kenny, R. C. Coombes, I. Oulie, K. B. Contractor, M. Miller, T. J. Spinks, B. McParland, P. S. Cohen, A.-M. Hui, C. Palmieri, S. Osman, M. Glaser, D. Turton, A. Al-Nahhas, E. O. Aboagye, Phase I Trial of the Positron-Emitting Arg-Gly-Asp (RGD) Peptide Radioligand 18F-AH111585 in Breast Cancer Patients The Journal of Nuclear Medicine. ,vol. 49, pp. 879- 886 ,(2008) , 10.2967/JNUMED.107.049452
J. K. Willmann, R. H. Kimura, N. Deshpande, A. M. Lutz, J. R. Cochran, S. S. Gambhir, Targeted Contrast-Enhanced Ultrasound Imaging of Tumor Angiogenesis with Contrast Microbubbles Conjugated to Integrin-Binding Knottin Peptides The Journal of Nuclear Medicine. ,vol. 51, pp. 433- 440 ,(2010) , 10.2967/JNUMED.109.068007
Wouter B. Nagengast, Marjolijn N. Lub-de Hooge, Sjoukje F. Oosting, Wilfred F.A. den Dunnen, Frank-Jan Warnders, Adrienne H. Brouwers, Johan R. de Jong, Patricia M. Price, Harry Hollema, Geke A.P. Hospers, Philip H. Elsinga, Jan Willem Hesselink, Jourik A. Gietema, Elisabeth G.E. de Vries, VEGF-PET Imaging Is a Noninvasive Biomarker Showing Differential Changes in the Tumor during Sunitinib Treatment Cancer Research. ,vol. 71, pp. 143- 153 ,(2011) , 10.1158/0008-5472.CAN-10-1088
A. J. Beer, M. Niemeyer, J. Carlsen, M. Sarbia, J. Nahrig, P. Watzlowik, H.-J. Wester, N. Harbeck, M. Schwaiger, Patterns of αvβ3 Expression in Primary and Metastatic Human Breast Cancer as Shown by 18F-Galacto-RGD PET The Journal of Nuclear Medicine. ,vol. 49, pp. 255- 259 ,(2008) , 10.2967/JNUMED.107.045526
Khalid A. Mohamedali, Sanjiv S. Gambhir, Weibo Cai, Michael G. Rosenblum, Qizhen Cao, Xiaoyuan Chen, Kai Chen, PET of Vascular Endothelial Growth Factor Receptor Expression The Journal of Nuclear Medicine. ,vol. 47, pp. 2048- 2056 ,(2006)
I.A. Mendichovszky, M. Cutajar, I. Gordon, Reproducibility of the aortic input function (AIF) derived from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) of the kidneys in a volunteer study European Journal of Radiology. ,vol. 71, pp. 576- 581 ,(2009) , 10.1016/J.EJRAD.2008.09.025