Diagnostic Ultrasound Combined With Glycoprotein IIb/IIIa–Targeted Microbubbles Improves Microvascular Recovery After Acute Coronary Thrombotic Occlusions

摘要: Background— The high mechanical index (MI) impulses from a diagnostic ultrasound transducer may be method of recanalizing acutely thrombosed vessels if the are applied only when microbubbles channeling through thrombus. Methods and Results— In 45 pigs with acute left anterior descending thrombotic occlusions, low-MI pulse sequence scheme (contrast sequencing) was used to image myocardium guide delivery high-MI (1.9 MI) during infusion either intravenous platelet-targeted or nontargeted microbubbles. A third group received no All groups half-dose recombinant prourokinase, heparin, aspirin. Contrast sequencing examined replenishment contrast within central portion risk area guided application impulses. Angiographic recanalization rates, resolution ST-segment elevation on ECG, wall thickening were analyzed. Pigs receiving micro...