The role of cytogenetics and molecular diagnostics in the diagnosis of soft-tissue tumors.

摘要: Soft-tissue sarcomas are rare, comprising 100 benign and malignant soft-tissue tumor entities defined. Not infrequently, these neoplasms exhibit overlapping clinicopathologic features posing significant challenges in rendering a definitive diagnosis optimal therapy. Advances cytogenetic molecular science have led to the discovery of genetic events tumors that not only enriched our understanding underlying biology but also proven be powerful diagnostic adjuncts and/or indicators targeted In particular, many characterized by recurrent chromosomal rearrangements produce specific gene fusions. For pathologists, identification fusions as well other characteristic mutational alterations aids precise subclassification. This review will address known or tumor-specific discuss approaches commonly used clinical practice identify them. Emphasis is placed on role pathology management tumors. Familiarity with provides important ancillary testing for pathologists include their armamentarium.