MRI of rheumatoid arthritis—image quantitation for the assessment of disease activity, progression and response to therapy

摘要: Magnetic resonance imaging (MRI) allows the direct visualization of many bone and soft tissue changes in rheumatoid arthritis. Synovitis volume, marrow oedema erosions are suitable for serial measurement. The outcome measures arthritis clinical trials (OMERACT) magnetic (RAMRIS) system is designed to allow straightforward, reproducible scoring all these features. Alternatively, synovial volumes may be directly quickly measured using semi-automated techniques. There potential similar systems measuring erosions. Dynamic contrast enhanced MRI depends on rate enhancement synovium after intravenous agent. Measurements depend underlying physiology inflamed synovium, particular vascularity capillary permeability which expected closely mirror inflammatory activity joint. from have been shown correlate with clinical, laboratory, histological inflammation, predict erosive progression respond rapidly various types treatment. They are, therefore, good disease activity, response therapy.