The collective nuclear migration of p53 and phosphorylated S473 of Akt during ellipticine-mediated apoptosis in human lung epithelial cancer cells.
作者： Jing-Ping Wang , Ya-Chu Yu , Shih-Ping Chen , Huan-Chang Liang , Chia-Wei Lin
DOI: 10.1007/S11010-015-2460-9
关键词:
摘要: Topoisomerase II inhibitor ellipticine effectively suppressed the growth of human non-small-cell-lung-cancer (NSCLC) epithelial cells. Previously, we reported drug activity was consummated through parallel nucleus migration p53 and Akt in A549 While inducing cell death, proved related to autophagy phosphorylated at S473. In addition, induced cytotoxicity p53-null H1299 cells with stable expression ectopic p53. this work, further demonstrated that dominant-negative (S473A) or shRNA inhibited ellipticine-mediated translocalization attenuated apoptotic death The presence predates death, assists translocation activation pathway. Growth inhibition collaborating Akt(473) lung cancer provided a new perspective topoisomerase as an effective therapy agent.
springer.com
paperity.org参考文章(51)
Claudia Cerella, Cindy Grandjenette, Mario Dicato, Marc Diederich, Roles of Apoptosis and Cellular Senescence in Cancer and Aging Current Drug Targets. ,vol. 17, pp. 405- 415 ,(2016) , 10.2174/1389450116666150202155915
Tomas Eckschlager, Rene Kizek, Marie Stiborova, Jan Hrabeta, Michaela Moserova, Jitka Poljakova, Marketa Göttlicherova, Barbora Kopejtkova, Marketa Dvorakova, Jana Hrebackova, Eva Frei, Anticancer agent ellipticine combined with histone deacetylase inhibitors, valproic acid and trichostatin A, is an effective DNA damage strategy in human neuroblastoma. Neuro endocrinology letters. pp. 101- ,(2011)
Grace L Chen, Liu Yang, TC Rowe, Brian D Halligan, Kathleen M Tewey, Leroy F Liu, Nonintercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II. Journal of Biological Chemistry. ,vol. 259, pp. 13560- 13566 ,(1984) , 10.1016/S0021-9258(17)47282-6
Mark E. Smulson, Cynthia Marie Simbulan-Rosenthal, Dean S. Rosenthal, Sudha Iyer, Hamid Boulares, Involvement of PARP and poly(ADP-ribosyl)ation in the early stages of apoptosis and DNA replication. Molecular and Cellular Biochemistry. ,vol. 193, pp. 137- 148 ,(1999) , 10.1007/978-1-4419-8740-2_20
Myoung Sook Kim, Mellissa Blake, Jin Hyen Baek, Glenda Kohlhagen, Yves Pommier, France Carrier, Inhibition of Histone Deacetylase Increases Cytotoxicity to Anticancer Drugs Targeting DNA Cancer Research. ,vol. 63, pp. 7291- 7300 ,(2003)
Alain Gouyette, Daniel Huertas, Jean-Pierre Droz, Jacques Rouesse, Jean-Louis Amiel, Pharmacokinetics of 2-methyl-9-hydroxyellipticinium acetate (NSC-264137) in cancer patients (phase I study) European Journal of Cancer and Clinical Oncology. ,vol. 18, pp. 1285- 1292 ,(1982) , 10.1016/0277-5379(82)90130-4
Marie Stiborova, Jitka Poljakova, Tomas Eckschlager, Rene Kizek, Eva Frei, Analysis of covalent ellipticine- and doxorubicin-derived adducts in DNA of neuroblastoma cells by the 32P-postlabeling technique Biomedical Papers. ,vol. 156, pp. 115- 121 ,(2012) , 10.5507/BP.2012.043
E. G. Russell, E. C. O’Sullivan, C. M. Miller, J. Stanicka, F. O. McCarthy, T. G. Cotter, Ellipticine derivative induces potent cytostatic effect in acute myeloid leukaemia cells Investigational New Drugs. ,vol. 32, pp. 1113- 1122 ,(2014) , 10.1007/S10637-014-0140-3
Kun-Chieh Chen, Tsung-Ying Yang, Chun-Chi Wu, Chi-Chih Cheng, Shih-Lan Hsu, Hsiao-Wen Hung, Jian-Wei Chen, Gee-Chen Chang, Pemetrexed Induces S-Phase Arrest and Apoptosis via a Deregulated Activation of Akt Signaling Pathway PLoS ONE. ,vol. 9, pp. e97888- ,(2014) , 10.1371/JOURNAL.PONE.0097888
Eva Martinkova, Anne Maglott, David Y. Leger, Dominique Bonnet, Marie Stiborova, Ken Takeda, Sophie Martin, Monique Dontenwill, α5β1 integrin antagonists reduce chemotherapy‐induced premature senescence and facilitate apoptosis in human glioblastoma cells International Journal of Cancer. ,vol. 127, pp. 1240- 1248 ,(2010) , 10.1002/IJC.25187