Quercetin and sulforaphane in combination suppress the progression of melanoma through the down-regulation of matrix metalloproteinase-9.

摘要: Malignant melanoma is one of the most common types cancer in US and worldwide. The epidemiological data suggest that dietary modification may reduce incidence this disease. Quercetin (3,5,7,3',4'-tetrahydroxyflavone), a flavonoid isolated from onion, exhibits anti-oxidant, anti-inflammatory anti-cancer effects. D,L-sulforaphane [1-isothiocyanato-4-(methylsulfinyl)-butane], cruciferous vegetable-derived isomer broccoli, highly effective protection against cancer. Matrix metalloproteinases (MMPs), extracellular matrix degrading enzymes, are involved embryogenesis, inflammation, angiogenesis MMP-9 particular plays crucial role regulation invasion, tumor growth metastasis. Previous studies have reported both quercetin sulforaphane independently metastasis breast, prostate, lung other cancers. However, combined effects on mechanism(s) actions underlying process not yet been investigated. In present study, we report for first time combination inhibit proliferation migration (B16F10) cells more effectively than either compound used alone. Moreover, these compounds significantly suppressed as compared to their individual use mouse model. This effect was predominantly due decrease expression tumors. Taken together, our findings revealed administration rather alone be approach treatment malignant melanoma.