MAPK genes interact with diet and lifestyle factors to alter risk of breast cancer: the Breast Cancer Health Disparities Study.
作者： Martha L. Slattery , Abbie Lundgreen , Esther M. John , Gabriela Torres-Mejia , Lisa Hines
DOI: 10.1080/01635581.2015.990568
关键词: Oncology 、 Endocrinology 、 Case-control study 、 Single-nucleotide polymorphism 、 Population 、 Estrogen receptor 、 Progesterone receptor 、 Body mass index 、 Menopause 、 Breast cancer 、 Biology 、 Internal medicine
摘要: Mitogen-activated protein kinases (MAPK) are integration points for multiple biochemical signals. We evaluated 13 MAPK genes with breast cancer risk and determined if diet lifestyle factors mediated risk. Data from 3 population-based case-control studies conducted in Southwestern United States, California, Mexico included 4183 controls 3592 cases. Percent Indigenous American (IA) ancestry was 104 informative markers. The adaptive rank truncated product (ARTP) used to determine the significance of each gene pathway risk, by menopausal status, genetic level, estrogen receptor (ER)/progesterone (PR) strata. MAP3K9 associated overall (PARTP = 0.02) strongest association among women highest IA 0.04). Several SNPs were ER+/PR+ tumors interacted dietary oxidative balance score (DOBS), folate, body mass index (BMI), alcohol cons...
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