The Aromatic Head Group of Spider Toxin Polyamines Influences Toxicity to Cancer Cells.

摘要: Spider venoms constitute incredibly diverse libraries of compounds, many which are involved in prey capture and defence. Polyamines often prevalent the venom target ionotropic glutamate receptors. Here we show that a novel spider polyamine, PA366, containing hydroxyphenyl-based structure is present several species tarantula, has selective toxicity against MCF-7 breast cancer cells. By contrast, polyamine from an Australian funnel-web venom, contains identical tail to PA366 but indole-based head-group, only cytotoxic at high concentrations. Our results suggest ring plays role cytotoxicity modification head group might lead more potent compounds with potential as treatments.