Effects of the 5-HT2C/2B receptor agonist 1-(3-chlorophenyl) piperazine on plasma glucose levels of rats.

作者: Yumi Sugimoto , Jun Yamada , Tomoko Yoshikawa , Kazuyoshi Horisaka

DOI: 10.1016/0014-2999(96)00189-6

关键词:

摘要: Abstract Acute administration of the 5-HT 2C 2B receptor agonist 1-(3-chlorophenyl)piperazine (mCPP, 5–10 mg/kg i.p.) induced hyperglycemia in rats. These changes were diminished a dose-dependent manner by 1 2 antagonist methysergide and 5-HT2A/2B/2C ritanserin. In addition, mCPP-induced was dose dependently ganglionic blocker hexamethonium prevented prior adrenodemedullation. Neither 5-HT2A ketanserin nor 3 4 (3-α-tropanyl)-1 H-indole-3-carboxylic acid ester (ICS 205-930) proved effective against hyperglycemia. Lastly, 2A 1-(2,5-dimethoxy-4-iodophenyl)2-aminopropane (DOI) increased plasma glucose levels through ketanserin- ritanserin-sensitive processes. Our results suggest that elicited mCPP is mediated 5-HT2C and/or receptors, turn adrenomedullary catecholamine release, whereas DOI involves receptors.

参考文章(21)
Lewandowska A, Maj J, Central serotoninmimetic action of phenylpiperazines. Polish journal of pharmacology and pharmacy. ,vol. 32, pp. 495- 504 ,(1980)
E Sanders-Bush, P J Conn, Relative efficacies of piperazines at the phosphoinositide hydrolysis-linked serotonergic (5-HT-2 and 5-HT-1c) receptors. Journal of Pharmacology and Experimental Therapeutics. ,vol. 242, pp. 552- 557 ,(1987)
K Szemeredi, D L Murphy, G Bagdy, B Kanyicska, Different serotonin receptors mediate blood pressure, heart rate, plasma catecholamine and prolactin responses to m-chlorophenylpiperazine in conscious rats. Journal of Pharmacology and Experimental Therapeutics. ,vol. 250, pp. 72- 78 ,(1989)
F Chaouloff, B Jeanrenaud, 5-HT1A and alpha-2 adrenergic receptors mediate the hyperglycemic and hypoinsulinemic effects of 8-hydroxy-2-(di-n-propylamino)tetralin in the conscious rat. Journal of Pharmacology and Experimental Therapeutics. ,vol. 243, pp. 1159- 1166 ,(1987)
A. Kłodzińska, E. Chojnacka-Wójcik, Hyperthermia induced bym-trifluoromethylphenylpiperazine (TFMPP) orm-chlorophenylpiperazine (m-CPP) in heat-adapted rats Psychopharmacology. ,vol. 109, pp. 466- 472 ,(1992) , 10.1007/BF02247725
Rochdi Bouhelal, Anis K. Mir, Role of the adrenal medulla in the metabolic and pressor actions of 8-OH-DPAT. British Journal of Pharmacology. ,vol. 105, pp. 159- 163 ,(1992) , 10.1111/J.1476-5381.1992.TB14228.X
Francis Chaouloff, Dominique Laude, Véronique Baudrie, Effects of the 5-HT1C/5-HT2 receptor agonists DOI and α-methyl-5-HT on plasma glucose and insulin levels in the rat European Journal of Pharmacology. ,vol. 187, pp. 435- 443 ,(1990) , 10.1016/0014-2999(90)90370-L
Francis Chaouloff, Dominique Laude, Véronique Baudrie, Ganglionic transmission is a prerequisite for the adrenaline-releasing and hyperglycemic effects of 8-OH-DPAT. European Journal of Pharmacology. ,vol. 185, pp. 11- 18 ,(1990) , 10.1016/0014-2999(90)90205-K
P.P.A. Humphrey, P. Hartig, D. Hoyer, A proposed new nomenclature for 5-HT receptors Trends in Pharmacological Sciences. ,vol. 14, pp. 233- 236 ,(1993) , 10.1016/0165-6147(93)90016-D