作者: Yumi Sugimoto , Jun Yamada , Tomoko Yoshikawa , Kazuyoshi Horisaka
DOI: 10.1016/0014-2999(96)00189-6
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摘要: Abstract Acute administration of the 5-HT 2C 2B receptor agonist 1-(3-chlorophenyl)piperazine (mCPP, 5–10 mg/kg i.p.) induced hyperglycemia in rats. These changes were diminished a dose-dependent manner by 1 2 antagonist methysergide and 5-HT2A/2B/2C ritanserin. In addition, mCPP-induced was dose dependently ganglionic blocker hexamethonium prevented prior adrenodemedullation. Neither 5-HT2A ketanserin nor 3 4 (3-α-tropanyl)-1 H-indole-3-carboxylic acid ester (ICS 205-930) proved effective against hyperglycemia. Lastly, 2A 1-(2,5-dimethoxy-4-iodophenyl)2-aminopropane (DOI) increased plasma glucose levels through ketanserin- ritanserin-sensitive processes. Our results suggest that elicited mCPP is mediated 5-HT2C and/or receptors, turn adrenomedullary catecholamine release, whereas DOI involves receptors.