Effect of 5-HT1A receptor activation on hypothalamic glucose.
作者： J VOIGT , B NWAISER , A REX , C MAYER , H FINK
DOI: 10.1016/J.PHRS.2004.03.006
关键词:
摘要: The somatodendritic 5-HT1A agonist 8-OH-DPAT reduces serotonergic activity and stimulates feeding in freely rats. Interactions between circulating glucose receptor expression related to have been described. aim of the present microdialysis study was (1) describe relation LH, (2) investigate if peripherally administered itself has an effect on extracellular lateral hypothalamus (LH) conscious Baseline concentrations were significantly different samples obtained from food deprived rats compared After re-feeding, a significant rise levels by 45% observed formerly In rats, (0.3 mg/kg, i.p.) reduced level LH significantly. brain antagonized pre-treatment with antagonist WAY 100635 (3 mg/kg which had no its own. data indicate, therefore, that hypothalamic is mediated receptors. contrast, same dose proven effective peripheral glucose. Only very high (1.8 hyperglycaemic periphery. conclusion, results show for first time, increases meal. demonstrate furthermore 8-OH-DPAT-induced changes level, implicating receptors being involved not only control 5-HT as shown before, but also
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