Mechanisms Involved in the Association between Periodontitis and Complications in Pregnancy

摘要: The association between periodontitis and some of the problems with pregnancy such as premature delivery, low weight at birth, preeclampsia (PE) has been suggested. Nevertheless, epidemiological data have shown contradictory data, mainly due to differences in clinical parameters assessment. Furthermore, microbial composition immune response aggressive chronic are not addressed by these studies. We aimed review current on periodontitis, mechanisms underlying this association. Shifts subgingival biofilm may occur during pregnancy, leading a potentially more hazardous community. Pregnancy is characterized physiological tolerance. However, infection leads shift maternal pathogenic pro-inflammatory response, production inflammatory cytokines toxic products. In women infected periodontal tissues act reservoirs bacteria their products that can disseminate fetus-placenta unit. severe patients, agents able activate signaling pathways locally extra-oral sites, including placenta-fetal unit, which only induce preterm labor but also lead PE restrict intrauterine growth. Despite evidences, effectiveness treatment preventing gestational complications was still established since it be influenced several factors severity disease, community, strategy, period throughout pregnancy. This lack scientific evidence does exclude need control inflammation patients protocols should validated.