Biological characterization of human monoclonal antibodies to rabies virus.

作者: B Dietzschold , M Gore , P Casali , Y Ueki , C E Rupprecht

DOI: 10.1128/JVI.64.6.3087-3090.1990

关键词:

摘要: Rabies virus antigen-specific human monoclonal antibodies (MAbs) that recognized either viral glycoprotein, ribonucleoprotein, or matrix proteins were generated. Only glycoprotein-specific MAb neutralized a variety of rabies viruses and protected laboratory rodents against lethal infection. The determinant by this does not appear to reside in previously defined antigenic sites the glycoprotein.

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