EFFECT OF IL-10 ON COLLAGEN-INDUCED ARTHRITIS IN MICE
作者： Y. Tanaka , T. Otsuka , T. Hotokebuchi , H. Miyahara , H. Nakashima
DOI: 10.1007/BF02280992
关键词:
摘要: In the present study we investigated effect of a potent anti-inflammatory cytokine, interleukin (IL)-10, on development collagen-induced arthritis (CIA) in mice. Each DBA1/J mouse was immunized with 200 micrograms native collagen and followed by booster injections at 3 weeks. rmIL-10 injected i.p. daily dose 100 ng/mouse. Mice were divided into four groups according to administration period rmIL-10. As result, 48-day course IL-10 treatment significantly suppressed severity arthritis. Among 4 groups, most pronounced suppression observed group which given from day 0 21. On other hand, there no significant differences serum IgG anti-type II (CII) titers between groups. Moreover, production cytokines (IL-6 tumor necrosis factor-alpha (TNF-alpha)) mediators (prostaglandin E2 (PGE2) nitric oxide (NO)) peritoneal macrophages seemed show clear correlation These results raise possibility that might be useful agent for suppressing progression CIA
springer.com
elsevier.com
sci-hub.se 参考文章(29)
A O'Garra, D F Fiorentino, P Vieira, T R Mosmann, A Zlotnik, M Howard, K W Moore, IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells. Journal of Immunology. ,vol. 146, pp. 3444- 3451 ,(1991)
S M Wahl, M J Bienkowski, G L Costa, J B Allen, H L Wong, Suppression of monocyte function and differential regulation of IL-1 and IL-1ra by IL-4 contribute to resolution of experimental arthritis. Journal of Immunology. ,vol. 151, pp. 4344- 4351 ,(1993)
Ara A. Vaporciyan, Michael S. Mulligan, Peter A. Ward, Michael L. Jones, Maureen C. Howard, Protective effects of IL-4 and IL-10 against immune complex-induced lung injury Journal of Immunology. ,vol. 151, pp. 5666- 5674 ,(1993)
G S Firestein, A E Berger, M M Paine, N J Zvaifler, D L Chapman, C Yu, D E Tracey, J G Chosay, IL-1 receptor antagonist protein production and gene expression in rheumatoid arthritis and osteoarthritis synovium. Journal of Immunology. ,vol. 149, pp. 1054- 1062 ,(1992)
J M Seyer, L K Myers, J M Stuart, K Terato, A H Kang, C S David, T cell epitopes of type II collagen that regulate murine collagen-induced arthritis. Journal of Immunology. ,vol. 151, pp. 500- 505 ,(1993)
A I Sperling, J A Bluestone, G M Peterman, C Spencer, Role of gamma delta T cells in murine collagen-induced arthritis. Journal of Immunology. ,vol. 151, pp. 6546- 6558 ,(1993)
Marcia L. Bliven, Paul H. Wooley, Mark B. Pepys, Ivan G. Otterness, Murine type II collagen arthritis: Association of an acute-phase response with clinical course Arthritis & Rheumatism. ,vol. 29, pp. 1131- 1138 ,(1986) , 10.1002/ART.1780290911
L. C. Green, K. Ruiz de Luzuriaga, D. A. Wagner, W. Rand, N. Istfan, V. R. Young, S. R. Tannenbaum, Nitrate biosynthesis in man. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 78, pp. 7764- 7768 ,(1981) , 10.1073/PNAS.78.12.7764
Catherine Haworth, Fionula M. Brennan, David Chantry, Martin Turner, Ravinder N. Maini, Mare Feldmann, Expression of granulocyte-macrophage colony-stimulating factor in rheumatoid arthritis: regulation by tumor necrosis factor-alpha. European Journal of Immunology. ,vol. 21, pp. 2575- 2579 ,(1991) , 10.1002/EJI.1830211039
T. Saxne, M. A. Palladino, D. Heinegãrd, N. Talal, F. A. Wollheim, Detection of tumor necrosis factor α but not tumor necrosis factor β in rheumatoid arthritis synovial fluid and serum Arthritis & Rheumatism. ,vol. 31, pp. 1041- 1045 ,(1988) , 10.1002/ART.1780310816