Intranasal topical flunisolide therapy in children with seasonal allergic rhinitis.

摘要: This study tested the effectiveness of flunisolide in treatment children with seasonal allergic rhinitis. Thirty-five between ages 5 and 14 years used an intransal preparation either (200 micrograms/day) or placebo for a 6-week double-blind parallel trial consisting 2-week baseline phase 4-week phase, conducted during period 'high' pollen counts Adelaide, South Australia. Flunisolide was effective reducing four symptoms hay fever: sneezing, stuffy nose, runny nose eye itch. Sixty-four percent flunisolide-treated group 33% placebo-treated noted substantial total control their fever (P < 0.05). The effect intranasal administration on pituitary-adrenal axis monitored by performing plasma cortisol measurements (a.m. p.m.) 24-hr urinary free excretion studies each patient. data confirmed that 200 micrograms/day does not suppress pituitary-adrenal-axis this young patient population.