Chronic pulmonary hypertension--the monocrotaline model and involvement of the hemostatic system.

摘要: Monocrotaline (MCT) is a toxic pyrrolizidine alkaloid of plant origin. Administration small doses MCT or its active metabolite, monocrotaline pyrrole (MCTP), to rats causes delayed and progressive lung injury characterized by pulmonary vascular remodeling, hypertension, compensatory right heart hypertrophy. The lesions induced MCT(P) administration in are similar those observed certain chronic diseases people. This review begins with synopsis the hemostatic system, emphasizing role endothelium since endothelial cell dysfunction likely underlies pathogenesis MCT(P)-induced pneumotoxicity. toxicology discussed, focusing on morphologic, mechanical, hemodynamic, biochemical molecular alterations that occur after toxicant exposure. Fibrin platelet thrombosis microvasculature occurs rats, several investigators have hypothesized thrombi contribute hypertension. evidence for involvement various components system remodeling reviewed. Current consistent platelets an altered fibrinolytic yet much remains be learned about specific events signals pathogenesis.