Semotiadil inhibits the development of right ventricular hypertrophy and medial thickening of pulmonary arteries in a rat model of pulmonary hypertension

摘要: This study was designed to compare the effects of semotiadil, a novel calcium antagonist, with those diltiazem on development right ventricular hypertrophy and medial thickening pulmonary arteries in rat model hypertension. Pulmonary hypertension induced by single injection monocrotaline (80 mg/kg). Twenty-four hours later (day 1), oral administration semotiadil (10, 30, or 100 mg/kg per day) (100 300 initiated. The wall thickness ventricle (RV), RV myocardial fiber diameter, percent artery thickness, area smooth muscle were determined day 28. magnitude all parameters significantly less group seven rats that received at than treated day. Semotiadil inhibits more effectively