A quantitative study of α-synuclein pathology in fifteen cases of dementia associated with Parkinson disease

摘要: The α-synuclein-immunoreactive pathology of dementia associated with Parkinson disease (DPD) comprises Lewy bodies (LB), neurites (LN), and grains (LG). densities LB, LN, LG together vacuoles, neurons, abnormally enlarged neurons (EN), glial cell nuclei were measured in fifteen cases DPD. Densities LN up to 19 70 times those respectively, depending on region. significantly greater amygdala, entorhinal cortex (EC), sectors CA2/CA3 the hippocampus, whereas middle frontal gyrus, sector CA1, dentate gyrus least affected. Low vacuoles EN recorded most regions. There differences numerical density between regions, but no statistical difference patients controls. In cortex, LB was similar upper lower laminae, while cortex. positively correlated. Principal components analysis suggested that DPD heterogeneous primarily affecting either hippocampus or data suggest DPD: (1) ratio varies (2) low are present brain (3) degeneration occurs across cortical laminae being particularly affected, (4) may represent same (5) heterogeneity result from variation anatomical pathway affected by cell-to-cell transfer α-synuclein.