Hydrogen‐supplemented drinking water protects cardiac allografts from inflammation‐associated deterioration

摘要: Summary Recent evidence suggests that molecular hydrogen has therapeutic value for disease states involve inflammation. We hypothesized drinking hydrogen-rich water (HW) daily would protect cardiac and aortic allograft recipients from inflammation-associated deterioration. Heterotopic heart transplantation with short-course tacrolimus immunosuppression orthotopic were performed in allogeneic rat strains. HW was generated either by bubbling gas through tap (Bu-HW) or via chemical reaction using a magnesium stick [Mg + 2H2O → Mg (OH)2 + H2] immersed (Mg-HW). Recipients given regular (RW), Mg-HW, Bu-HW, Mg-HW had been subsequently degassed (DW). Graft survival assessed palpation heartbeat. Drinking Bu-HW remarkably effective prolonging graft reducing intimal hyperplasia transplanted aortas as compared grafts treated RW DW. Furthermore, T cell proliferation significantly inhibited the presence of vitro, accompanied less production interleukin-2 interferon-γ. Hydrogen treatment also associated increased ATP levels activity enzymes mitochondrial respiratory chain. prolongs allografts reduces allografts.