A Keratinocyte-Responsive γδ TCR Is Necessary for Dendritic Epidermal T Cell Activation by Damaged Keratinocytes and Maintenance in the Epidermis
作者： Julie M. Jameson , Gabrielle Cauvi , Deborah A. Witherden , Wendy L. Havran
DOI: 10.4049/JIMMUNOL.172.6.3573
关键词:
摘要: A unique population of T lymphocytes, designated dendritic epidermal cells (DETC), homes to the murine epidermis during fetal development. DETC express a canonical gammadelta TCR, Vgamma3/Vdelta1, which recognizes Ag expressed on damaged, stressed, or transformed keratinocytes. Recently, were shown play key role in complex process wound repair. To examine TCR localization epidermis, maintenance skin, and activation vivo, we analyzed TCRdelta(-/-) mouse. Unlike previous reports skin was found be devoid any DETC, discovered that mice have alphabeta TCR-expressing with polyclonal Vbeta chain repertoire. The are not retained over life animal, suggesting is critical for skin. Although can activated response direct stimulation, they do respond keratinocyte damage. Our results suggest keratinocyte-responsive necessary damage epidermis.
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