Mesenchymal stromal cells for cell therapy: besides supporting hematopoiesis

摘要: Mesenchymal stromal cells (MSC) have attracted the attention of scientists and clinicians due to their self-renewal, capacity for multipotent differentiation, immunomodulatory properties. Some essential problems remain be solved before clinical application MSC. Platelet lysate (PL) has recently been used as a substitute FBS in MSC amplification vitro achieve clinically applicable numbers In addition promising trials regenerative medicine, such treatment major bone defects myocardial infarction, shown therapeutic effect other than direct hematopoiesis support hematopoietic reconstruction. It confirmed that promote cell engraftment immune recovery after allogeneic stem transplantation, probably through provision cytokines, matrix proteins, cell-to-cell contacts. Their suppressive effects on cells, including T B NK DC suggest MSCs novel therapy GVHD autoimmune disorders. These thus present candidates cellular fields